In addition, Nutlin-3 can also induce the formation of heat shock protein 70 (HSP70)-MDM2 foci (Fig. 1c and d), consistent with a recent report that demonstrated induction of MDM2 and HSP70 in blood cancer cells in response to the Nutlin ligand [41]. The gene discussed is MDM2; the disease is hematopoietic and lymphoid system neoplasm.