Results showed that CETN2, MKI67, ARL13B, and SETDB1 with lower expression level were related to a significantly longer survival time; meanwhile, high expression of CALN1, ELAVL3, ADCY3, SYN2, ARL13B, SLC12A5, and SOD1 were associated with better overall survival of patients with GBM. Here, SETDB1 is linked to glioblastoma.