ESR2 and glioblastoma: Previous study indicated that genes such as estrogen receptor 2 (ESR2), ELOVL fatty acid elongase 6 (ELOVL6), iroquois homeobox 3 (IRX3), PDZ binding kinase (PBK), centromere protein A (CENPA), and kinesin family member 15 (KIF15) were significantly associated with the prognosis of GBM, suggesting that these genes might be potential targets for GBM treatment [4, 5].