SYN2 and glioblastoma: By analyzing the expression of the hub genes in the TCGA GBM data, we observed that the expression levels of 10 hub genes were consistent with the results of microarray datasets, including MKI67, ARL13B, SETDB1, ELAVL3, ADCY3, SOD1, CALN1, SYN2, and SLC12A5. Notably, compared with normal samples, the expression level of MKI67, ARL13B, and SETDB1 was significantly up-regulated in GBM samples, while ELAVL3, ADCY3, SOD1, CALN1, SYN2, and SLC12A5 were markedly down-regulated (Fig. 5 and Table 3).