In pancreatic cancer, researchers have found that the KrasG12D mutation up-regulated the levels of interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) through activating the MEK/ERK pathway inducing regulatory T cells (Tregs) conversion and immunosuppressive [44]. Here, TGFB1 is linked to familial pancreatic carcinoma.