Among the factors linking obesity to ASCVD, cell adhesion molecules (CAMs) such as endothelial leukocyte adhesion molecule-1 (E-selectin or cluster of differentiation (CD) 62E), platelet (P)-selectin (CD62P), intercellular cell adhesion molecule-1 (ICAM-1; CD54), and vascular cell adhesion molecule-1 (VCAM-1, CD106) may play a mechanistic role. The gene discussed is SELE; the disease is obesity due to melanocortin 4 receptor deficiency.