According to this study, which also focused on cell cultures, the inhibition of ECI2 gene expression led to acute metabolic stress in prostate cancer cells in the cell culture, and the targeting of ECI2 (or more generally lipid degradation) may have a therapeutic significance, although the exact mechanism(s) by which ECI2 knockdown inhibits cancer cell proliferation is unknown. The gene discussed is ECI2; the disease is prostate carcinoma.