The evaluation of the significance of HNF1B in the carcinogenesis of solid tumors has recently been gaining importance, along with the data gained from several genome-wide association studies (GWAS), suggesting that certain HNF1B single nucleotide polymorphisms (SNPs) are associated with either an increased or decreased risk of several solid tumors (such as ovarian carcinoma, endometrial carcinoma and prostate carcinoma)42–46. The gene discussed is HNF1B; the disease is prostate carcinoma.