Despite the fact that the involvement of HNF1B in prostate carcinogenesis is a complex and still unresolved issue with some controversies, according to current knowledge and most of the studies published, the increased expression of HNF1B may protect against prostate cancer, suggesting that in the prostate HNF1B seems to have an oncosuppressive role7,10. The gene discussed is HNF1B; the disease is Familial prostate cancer.