Our study found that early pressure overload of the right heart chamber induces an increased synthesis of thick filament proteins, such as myosin-7, which is a protein strongly linked to the hypertrophic cardiomyopathy development39, and concurrently inhibits apoptotic and autophagy pathways (decrease in protein/nucleic acid deglycase DJ-1, which is an anti-oxidative and autophagy modulator protein) that further promote cardiac hypertrophy40. The gene discussed is MYH7; the disease is hypertrophic cardiomyopathy.