Four of the observed proteins were altered in both RA and LV samples at early PAH stage and have expressed the same direction of change with similar strength (increase in Myosin-7, Methylmalonate-semialdehyde dehydrogenase, Long-chain specific acyl-CoA dehydrogenase and decrease in LDHA) (Table 2). The gene discussed is MYH7; the disease is pulmonary arterial hypertension.