In the context of sepsis, the effects of the MyD88 signaling pathway are inconclusive as the presence of MyD88 has been reported to be beneficial or detrimental for sepsis outcomes20–24, on the other hand, the role of the TICAM2/TRIF-dependent pathway in neutrophil exhaustion during the sepsis pathogenesis is not well understood. This evidence concerns the gene TICAM2 and Sepsis.