Together, our data reveal that murine neutrophils with prolonged LPS stimulation recapitulate key features of neutrophils from sepsis patients and those with high risks of organ failure, including upregulated PD-L19, ICAM16,7, CD298 and downregulated CD62L29,30 as well as CXCR210,31. This evidence concerns the gene ATP1B3 and Sepsis.