In males and females, participants having a SPISE below the cutoff for MetS prediction had significantly higher values of WC, SBP, DBP, glycemia, insulin, HOMA-IR, TChol, LDL-chol, TG, TG/HDL-chol ratio, and hs-CRP, and significantly lower values of HDL-chol compared to males and females having the test negative. This evidence concerns the gene INS and metabolic syndrome.