Insulin resistance (IR), reduced responsiveness of a target cell or a whole organism to the insulin concentration to which it is exposed, is the prelude of major cardiometabolic disorders, such as coronary heart disease, stroke, Metabolic Syndrome (MetS), non-alcoholic fatty liver disease (NAFLD) and type-2 diabetes (T2D)1,2. The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.