TREM1 and metabolic disease: Cluster 3 (423 genes) DEGs that are relatively upregulated at 4-weeks exposure (CD45.2 monocytes and AΦ) were associated with the homeostatic process, response to oxidative stress and regulation of acute inflammatory response, and pathways and included IL-10 signaling and activation of liver X receptors and retinoid X receptors (important regulators of macrophages and key players in inflammatory and metabolic disorders)20 and TREM1 signaling.