Metabolic stress caused by limited energy supply during the process of rapid growth is common in solid tumours, including CRC.24,25 Glucose deficiency is one of the main patterns of metabolic stress because of the striking dependence of cancers on glucose as a carbon resource.26 Our preliminary bioinformatics analysis using public datasets demonstrated that the GLUT3-encoding gene SLC2A3 was remarkably upregulated in CRC tissues and that high expression of SLC2A3 but not SLC2A1 was negatively associated with the overall survival of patients with CRC. This evidence concerns the gene SLC2A3 and hyperinsulinemic hypoglycemia, familial, 4.