CREB1 and colorectal carcinoma: It was reported that CREB1 can be recognized and stimulated by AMPK by phosphorylating it at Ser133.30 In CRC cells, stimulation of AMPK activity by AICAR treatment activated CREB1 and upregulated GLUT3 expression (Fig. 6d), while repression of AMPK activity by compound C treatment or by downregulation of AMPK reduced phosphorylated CREB1 and downregulated GLUT3 (Fig. 6f and Supplementary Fig. S6c).