Previous studies have confirmed SLC2A1 as a prominent oncogenic gene that promotes remarkable enhancement of cell proliferation.13,14 GLUT2 is the principal transporter for transfer of glucose between liver and blood.15 Previous function analysis revealed that GLUT2 is mainly responsible for blood glucose monitoring and the control of pancreatic hormone secretion.16 A prognostic study conducted in liver cancer found that high expression of GLUT2 is associated with inferior survival of patients.17 However, the investigation of GLUT2 in CRC is scarce. The gene discussed is SLC2A1; the disease is colorectal carcinoma.