To determine whether GLUT3-mediated glucose utilization is requisite for the rapid growth of CRC cells in vitro and in vivo, we silenced SLC2A3 in two cell lines, HCT116 and SW620, which show high baseline expression of GLUT3, by using small short hairpin RNA (Fig. 2a; Supplementary Fig. S4a). The gene discussed is SLC2A3; the disease is colorectal carcinoma.