SLC2A3 and colorectal carcinoma: Vitamin C in cell culture medium can be oxidized to DHA with a half-life of 70 min.31 After vitamin C treatment for 24 h, relative to control cells, CRC cells with ectopic GLUT3 expression exhibited an obvious increase in intracellular ROS levels (Supplementary Fig. S7a) and a severe decrease in intracellular GSH levels (Supplementary Fig. S7b).