SLC2A3 and colorectal carcinoma: In a previous study, we conducted a comprehensive metabolomics investigation of tissue samples from 193 patients with CRC and found that glucose levels were strikingly reduced in the CRC tissues of patients compared to adjacent non-tumour tissues.27 Glucose scarcity results in decreased energy production and activation of AMP-activated protein kinase (AMPK), an upstream regulator of many metabolic genes.28,29 Therefore, we hypothesized that glucose deficiency in the TME enhanced AMPK signalling to elicit GLUT3 expression.