The integrity of the blood-brain barrier may also be relevant in stroke: in patients with acute ischaemic stroke, NMDAR antibodies were associated with larger stroke lesions in patients with a “leaky” blood-brain barrier, as indicated by APOE4 status, and conversely, in patients with an intact blood-brain barrier NMDAR antibodies were associated with smaller stroke lesion size113. The gene discussed is APOE; the disease is Stroke.