The HSP70 is a highly conserved family of molecular chaperone that plays central role in cellular proteostasis by aiding the folding/refolding, oligomerization, and turnover of client proteins5, which collectively serve to protect cells from physiological, pathological, environmental, and pharmacological insults and render HSP70 a critical determinant of cancer cell resistance against therapeutics6,7. Here, HSPA1A is linked to cancer.