We found that the high level of MKK3 expression is associated with the increased overall tumor to stroma ratio (Spearman R = 0.38, p-value < 0.01, q-value = 0.04, Fig. 6c), and fewer discrete tumor “nests” (Spearman R = −0.46, p-value < 0.01, q-value < 0.01, Fig. 6d). Here, MAP2K3 is linked to neoplasm.