On comparing the performance of the EPI test (AUC 0.66, 95%CI: 0.55–0.78) with alternative models, the EPI test was superior to PSA only (AUC 0.54, 95%CI: 43–66), and the ERSPC-RC (AUC 0.47, 95%CI: 0.36–0.58), for predicting ≥GG2 PCa, (Fig. 1a). This evidence concerns the gene KLK3 and posterior cortical atrophy.