HCO<sub>3</sub><sup>-</sup> level was the most important factor deciding euthyroid or ESS on logistic regression analysis (OR = 0.844, P = 0.004, 95%CI = 0.751-0.948).<h4>Conclusions</h4>Lower levels of free thyroid hormones and occurrence of ESS were associated with a higher degree of acidosis in children with DKA/DK. The gene discussed is TG; the disease is acidosis disorder.