APOL1 and ischemia: On the one side DGF is known to correlate with kidney ischemic injury [24], on the other ischemia severity (given as diminution of haemoglobin concentration) was shown to foster an association between the apolipoprotein 1 (APOL1) gene and MYH9-associated predispositions to sickle cell disease nephropathy [13, 14].