BUB1B and cervical squamous intraepithelial neoplasia: Conversely, another study found that when a senescent state was induced in gastric cancer cell lines by silencing Mad2 and BubR1, this led to decreased cell proliferation, migration and invasion and this phenotype was aggravated when the CIN rates were further increased by concomitant treatment with the microtubule poison paclitaxel [122].