MAP3K7 and Crohn disease: Furthermore, single nucleotide polymorphisms (SNPs) in the TAK1-TNF pathway including MAP3K7 and TNFSF18 (Crohn's disease), TNFSF14 and 16NFKB1 (ulcerative colitis), TRAF3IP2 and TNFAIP2 (general inflammatory bowel disorder) are associated with higher risk for disease development [32–34].