Our preliminary research has shown that ESCC might be locally characterized by upregulated expression of genes encoding glucose transporter 1 (GLUT1) as well as inducible nitric oxide synthase (NOS) and ornithine decarboxylase (ODC) of the L-arginine/nitric oxide (NO)/polyamine pathway [6]. This evidence concerns the gene NOS2 and esophageal squamous cell carcinoma.