Another group of authors, who discovered the connection between TGM3 gene sequence alterations and BCC, hypothesized that compromised TGM3 activity might disrupt the normal differentiation and cell death program of corneocytes and the formation of CCE affecting skin barrier function, which in combination may cause inflammation leading to epidermal hyperplasia and the creation of tumor-promoting environment [126]. Here, TGM3 is linked to skin basal cell carcinoma.