Though the authors did not suggest any molecular mechanism for the downregulation of TGM3 in BCC, they proposed that the differentiation-correlated profile, including the correlation of expression between TGM1, TGM3, TGM5, loricrin, and involucrin, is lost in BCC in contrast to normal skin, SCC, and melanoma that was shown using the gene array. The gene discussed is LORICRIN; the disease is skin basal cell carcinoma.