In the univariate analysis of the whole study population, age ≥70 years (HR = 2.27, 95% CI 1.29–3.98), ECOG PS ≥ 1 (HR = 2.36, 95% CI 1.34–4.13), CCI ≥ 8 (HR = 2.11, 95% CI 1.18–3.80), primary tumor resected (HR = 0.22, 95% CI 0.10–0.47), pN2 (HR = 1.65, 95% CI 1.07–2.54), G3 tumor grade (HR = 2.29, 95% CI 1.24–4.22), BRAF V600E mutation (HR = 5.16, 95% CI 2.20–12.10) were those variables that significantly predict overall survival (Table 2). The gene discussed is BRAF; the disease is neoplasm.