BRAF and neoplasm: (Figure 2A–H) However, in a multivariate model including age, ECOG PS, CCI, primary tumor resected, and stage, only tumor grade (HR = 5.26, 95% CI 1.98–14.01) and BRAF mutation status (3.71, 95% CI 1.07–12.89) were independent prognostic factors for OS (Table 2) (Figure 2F,H).