Figure 1D illustrates the lack of overlapping genes among up-regulated miRs. There is only one common gene target, POLD3, that is shared between miR-632 and miR-331-5p, but not miR-616-3p. Overall, there is a considerably reduced number of validated gene targets for the up-regulated miRs compared to the down-regulated; still, a number of resultant genes have documented roles in cell proliferation, DNA damage response, cancer stemness, extracellular matrix organization, and genome stability (Table S5). This evidence concerns the gene POLD3 and cancer.