SMAD4 and cancer: Combined, these miRs presumably down-regulate 157 gene targets, many with well documented roles in cell proliferation, signal transduction, DNA damage response, cancer stemness, adhesion, extracellular matrix (EMT) organization, and genome stability (i.e., MDM4, CDK4, MSH6, XIAP, ETS1, RHOA, SMAD4, POLD3, COL3A1, FGF2, FOXF2, and SOX5).