The TCGA platform, for example, shows upregulation of MMP16 in the proneural type of glioblastoma only, the REMBRANDT database reports moderate upregulation in low-grade gliomas and glioblastoma (both retrieved from betastasis.com), while a recent report using a French dataset calculated an approximately 2-fold upregulation [28]. The gene discussed is MMP16; the disease is central nervous system cancer.