CYCS and neoplasm: However, despite the increased cell membrane TRAIL-R2 death receptor [32], a potential mediator of extrinsic apoptosis, as well as of the mitochondrial BAX and cytoplasmic cytochrome c, the promoters of intrinsic programmed cell death, researchers only detected cleaved/activated caspase-3 positivity in some peri- and intratumoral inflammatory cells, but not in tumor cells.