Other tumor models where mEHT treatment induced elevated p53 and p21waf1 levels included HepG2 hepatocellular carcinoma cell cultures [38] and B16F10 melanoma cells (with Cdkn2a-del, which downregulates Tp53, and Braf mutations), both in culture and mouse xenografts [42]. The gene discussed is TP53; the disease is neoplasm.