Besides recruiting the caspase cascade upon heat and cell stress, p53 activation can also upregulate the cyclin-dependent kinase inhibitor p21waf1 (CDKN1A) as it was shown both at mRNA and protein levels between 3–9 h and 24 h post-mEHT treatment, respectively, in C26 cell cultures and also in tumor allograft sections [29]. The gene discussed is TP53; the disease is neoplasm.