The ICD is known to be supported by tumor destruction, either by necrosis, apoptosis, or mixed death pathways in response to chemotherapy (e.g., doxorubicin, oxiplatin) [78,79]; radiotherapy [80]; epidermal growth factor receptor (EGFR) targeting cetuximab immunotherapy [81]; or immune checkpoint inhibition therapy [82]. The gene discussed is EGFR; the disease is neoplasm.