EDN1 and infection: Following E-30 infection and regardless of the side of infection, we noted the overexpression of genes such as CXCL2, CXCL3, CXCL10, IFNβ-1, INFλ-1, -2, -3, IFIT-1, -2, -3 and EDN1, which are commonly upregulated upon infection, and, therefore, indicate important defense mechanisms by HIBCPP and other epithelial cells [46,47].