We evaluated the following targets for Let-7a: CCR7, a chemokine receptor and validated Let-7a target involved in breast cancer metastasis to lymph nodes [59,71,72]; eukaryotic translation initiation factor 4G2 (eIF4G2), a predicted target involved in cancer progression and metastasis [73,74]; cyclin D1, a validated target critically involved in progression, chemoresistance and survival [75,76,77]; and vinculin a predicted target involved in directionality of migration and focal adhesion dynamics [78,79]. The gene discussed is CCND1; the disease is breast cancer.