The effect of LASP1 on focal adhesion dynamics [13] through its interaction with zona occludens 2 (ZO-2) [14] and zyxin [15], as well as its impact on motility through association with the chemokine receptor CXCR4 [16] and vimentin [17], suggests an intricate role for LASP1 in breast cancer metastasis. The gene discussed is LASP1; the disease is breast carcinoma.