Interestingly, a study investigating the co-operation of H19 and miR-675 in HCC reported that knockdown of H19 and miR-675 promoted migration and invasion of HCC cells through the AKT/GSK-3β/Cdc25A signaling pathway [99], suggesting that H19 and/or miR-675 function as tumor suppressors. This evidence concerns the gene GSK3B and hepatocellular carcinoma.