PAQR9 and metabolic dysfunction-associated steatohepatitis: Furthermore, liver-specific ablation of Blnc1 protected the Blnc1 conditional knockout mice from high fat diet-induced hepatic steatosis and insulin resistance and ameliorated diet-induced NASH pathogenesis in mice, suggesting that Blnc1 could be a potential therapeutic target for treatment of NAFLD and NASH [117].