The lncRNA regulator of Akt signaling associated with HCC and RCC (LNCARSR) binds to the Yes1-associated transcriptional regulator (YAP1) to inhibit its phosphorylation nuclear translocation, resulting in activation of the IRS2/AKT pathway, leading to increased lipid accumulation, cell proliferation, invasion and cell cycle [34]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.