SPI1 and hepatocellular carcinoma: Furthermore, gankyrin-associated lincRNA in hepatocellular carcinoma (Linc-GALH) binds to DNA methyltransferase 1 (DNMT1) to regulate its ubiquitin status [32], while the long intergenic non-protein coding RNA 324 (LINC00324) was shown to bind Spi-1 proto-oncogene (SPI1, also known as PU.1) to regulate the expression of Fas ligand (FASLG) [33].