NTRK2 and congenital rubella syndrome: Regarding the TRKB-PI3K-AKT pathway, we observed, in the crude synaptosomal fraction, a significant effect of CRS (F1–17 = 7.836, p < 0.05, two-way ANOVA) and ARS (F1–17 = 8.168, p < 0.05, two-way ANOVA) on pAKT Ser473.