The confocal microscopy analysis reveals the co-immunolocalization of NGB with collagen I, the most abundant collagen in ECM of tumors including BC [15,16], principally at the level of the extracellular matrix as indicated by the absence of any nuclear DAPI signals (Figure 1; merged image; white arrows and square of merge image detail), strengthening the idea of an in vivo extracellular NGB localization. The gene discussed is NGB; the disease is breast cancer.