Among different factors, including growth factors, cytokines, chemokines, and microRNAs, released by breast cancer cells to cope with stressful conditions altering the tumor microenvironment [1], the 17β-Estradiol (E2)-inducible compensatory protein named neuroglobin (NGB) [7] deserves particular consideration for its pro-survival and anti-apoptotic role in BC [8]. Here, NGB is linked to breast carcinoma.