TP53 and cancer: AMPK seems to have a dual role, as on one side, it seems to suppress cancer cell proliferation by leading to mTORC1 inhibition, p53 activation and other transcriptional responses, while on the other side, it helps to promote cancer cell survival by activating ATP-generating pathways (such as glycolysis, fatty acid uptake and oxidation and mitochondrial biogenesis) [15].