Interestingly, an analysis of the gene expression profile of hMSC from AML patients (hMSC-AML) compared to healthy donors hMSCs (hMSC-HD) showed that BMP4 expression was decreased in hMSC-AML [88] and could be regulated by the Wnt signaling pathway [88] and could be regulated by the Wnt signaling pathway [89]. This evidence concerns the gene BMP4 and acute myeloid leukemia.