Other authors lingered on the spike (S) envelope protein of the currently emerging virus (CoV) inducing severe acute respiratory syndrome (SARS) to explain the crucial role of glycoprotein in infection initiation by binding receptor-binding domain of S protein to the cellular receptor ACE2 and in the phase of viral envelope fusion with the host-cell membrane through the endosomal pathway [44]. The gene discussed is CHMP5; the disease is severe acute respiratory syndrome.