BMP2 and cyst: Although a dose-response relationship has been reported for BMP-2 in the clinics with higher doses being more beneficial for the healing outcome [20], thorough testing of the optimal BMP-2 dosage regime unraveled that therapeutic concentrations can induce robust bridging with normal microarchitecture, while supraphysiological doses resulted in bridging as well, albeit causing lower bone quality with abnormal cyst-like bone structure [27].