Alvarez-Miguei et al. [144] reported that, although both TRPC3 and TRPC6 were expressed in mesenteric arteries and possibly formed heteromeric TRPC3/TRPC6 channels, only TRPC3 activity was associated with greater basal and agonist-induced contractions of mesenteric arteries from hypertensive animals compared to those isolated from normotensive control mice, implicating TRPC3 channels in the pathogenesis of essential hypertension. The gene discussed is TRPC3; the disease is hypertensive disorder.