TRPC1 and pulmonary arterial hypertension: Later, Xia et al. reported that TRPC1–TRPC6 Double KO mice exhibited pulmonary hypotension and were better protected from chronic-hypoxia-induced pulmonary hypertension as compared to TRPC1 KO and TRPC6 KO mice [164], suggesting that the combined actions of TRPC1 and TRPC6 channels could exhibit larger influence on pulmonary artery remodeling under chronic hypoxia.