Interestingly, it was demonstrated that the protection conferred by TRPC3 deletion is not only due to the reduction of Ca2+ influx mediated by TRPC3, but also through the modulation of CaV1.2 expression, which is downregulated in TRPC3 KO mice and leads to reduced response in phenylephrine-induced cardiac hypertrophy [131]. The gene discussed is TRPC3; the disease is cardiac hypertrophy.