COA4 and acute respiratory distress syndrome: Interestingly, we found that genes associated with mitochondrial functions, such as Mitochondrial Apoptogenic Protein 1 (Apopt1), also known as cytochrome c oxidase assembly factor 8 (Coa8); and Coa4; mitochondrial cytochrome c oxidases (Cox6a1, Cox7a1, Cox18); and apoptosis-inducing factor 2-homologous mitochondrion-associated inducer of death (Aifm2), were upregulated in lung-infiltrating MNCs following THC treatment in SEB-induced ARDS.