Interestingly, stimulation of AMPK with subsequent increase of nitric oxide concentrations occurred to be a mechanism by which liraglutide (glucagon-like peptide 1 receptor agonist), a drug used for diabetes and obesity treatment in humans, induces WAT browning and increases energy expenditure and mitochondrial biogenesis in BAT in animal models of obesity [139]. Here, GLP1R is linked to obesity due to melanocortin 4 receptor deficiency.