ST3GAL3 and malignant colon neoplasm: Intriguingly, the induction of epithelial-mesenchymal transition (EMT) in colon cancer led to the upregulation of FUT3, ST3GAL3 and ST3GAL4, which are implicated in the final steps of the biosynthesis of sLex/a, suggesting a significant link between those Lewis antigens and EMT in colon carcinoma [57].