In this regard, we have also shown that an increase in sLex in pancreatic cancer cells overexpressing ST3GAL3 alters the glycosylation pattern and modulates the function of important cell membrane glycoproteins, such as α2β1 integrin and E-cadherin, involved in tumor cell adhesion and invasion mechanisms [34]. This evidence concerns the gene CDH1 and familial pancreatic carcinoma.