Our present study aimed to investigate the combination effect of 5-FU with either CX-4945 or a new inhibitor of protein kinase CK2, namely 14B (4,5,6,7-tetrabromo-1-(3-bromopropyl)-2-methyl-1H-benzimidazole), on the viability of triple-negative MDA-MB-231 breast cancer cells. This evidence concerns the gene WEE1 and breast carcinoma.