NEIL2 and infection: (c) Our current results showed that the measurement of 8-hydroxy guanosine (Figure 3D), LA-PCR (Figure 3E), and the accumulation of double-strand breaks by γH2AX staining (Figure 4A,B) conclusively showed a higher level of DNA strand-break accumulation in WT cells after Fn infection (with a lower NEIL2 expression level).