The effect of NEIL2 on the expression of proinflammatory cytokines was further assessed using the WT vs. Neil2 KO mouse EDMs following infection with Fn. It was found that Fn infection upregulated KC (IL-8) transcripts in both the EDMs; however, NEIL2 KO EDMs had a four-fold higher KC compared to the WT EDMs following Fn infection (Figure 3B). This evidence concerns the gene CALCA and infection.