However, MPN patients with GlcSph-reactive IgGs had a distinct cytokine profile, with significantly higher levels of IL-8, IP-10, HGF, TGF-β1, TGF-β3, PDGF-BB, VEGF, MIP-1β, IL-9 and eotaxin, and low levels of IFN-α2. This evidence concerns the gene CCL4 and myeloproliferative disorder.