TGFB3 and essential thrombocythemia: Firstly, we determined that wild-type UT-7 cells secrete 27/42 cytokines or chemokines, as measured in cell supernatants, including 5/8 cytokines overexpressed in ET compared to PV (IL-9, IL-17, MIG, TGF-β2, TGF-β3) (Figure 4a).