EGFR and neoplasm: Given the early studies that the activation of the epidermal growth factor receptor (EGFR) pathway is associated with tumor proliferation and radioresistance in patients [14], we examined the expressions of EGFR, phosphatase and tensin homolog (PTEN), signal transducer and activator of transcription 3 (STAT3), and heat shock protein 90 (HSP90) to evaluate the influence of RT and TNuF (Figure 2).