In several in vitro tumor models, Jung et al. [75] identified a relationship between the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2; NFE2L2/NRF2), a master regulator of the antioxidant response that is highly implicated in multiple hallmarks of cancer [76], and the mitochondrion. Here, NFE2L2 is linked to neoplasm.