Somatic mutation in genes for NF-κB regulators has been observed in NPC cells, with dominant alteration in NF-κB inhibitor alpha (NFKBIA), CYLD lysine 63 deubiquitinase (CYLD), and tumor necrosis factor receptor-associated factor 3 (TRAF3) [27,133,134]. Here, NFKB1 is linked to nasopharyngeal carcinoma.