PHLPP2 and Alzheimer disease: Among the set of genes, we highlight some well-known AD-related genes, but also some novel genes, such as PHLPP2, ARFGAP1, and CATSPER1. The miRNA–gene interactions described in the present study are a valuable set of regulatory elements that must be used as potential candidates as biomarkers of cognitive and severe dementia, however, it requires more functional studies to validate these interactions.