Agonists of GPER1, such as 1-[4-(6-bromobenzo[1,3] dioxol-5yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone (G-1) have been tested as an anticancer by suppressing cancer cell proliferation [30]. The gene discussed is GPER1; the disease is cancer.