Among the set of genes, we highlight some well-known AD-related genes, but also some novel genes, such as PHLPP2, ARFGAP1, and CATSPER1. The miRNA–gene interactions described in the present study are a valuable set of regulatory elements that must be used as potential candidates as biomarkers of cognitive and severe dementia, however, it requires more functional studies to validate these interactions. This evidence concerns the gene ARFGAP1 and Alzheimer disease.