Moreover, RCC patients, who have an average age at diagnosis of 65 years, commonly suffer from comorbidities including HTN and BPH (if male), notwithstanding the common association of HTN with RCC as a paraneoplastic syndrome secondary to renin and adrenocorticotropic hormone (ACTH) secretion, parenchymal or ureteral compression, and polycythaemia or an arterio-venous fistula. This evidence concerns the gene POMC and hypertensive disorder.