Whereas eNOS-derived NO (in SECs) is pivotal to maintain physiological regulation of sinusoidal tone, maintain HSCs in a quiescent state, and is reduced in liver cirrhosis, iNOS is upregulated in response to pathological conditions, such as endotoxin or bacterial infections and can be found in all liver cells [81,88,89,90,91,92]. The gene discussed is NOS2; the disease is cirrhosis of liver.