WZYZ pill primarily acting on testicular spermatogenic epithelial cells, which directly affects the differentiation and development of spermatogenic cells and restores spermatogenic function.[20] It has been shown that WZYZ pill can significantly improve the semen quality and increase serum testosterone (T) and luteinizing hormone (LH) levels in male infertility patients.[7,21] WZYZ pill can remarkably enhance male semen parameters. The gene discussed is PLOD1; the disease is male infertility.