GH1 and Timothy syndrome: Over half of TS patients have a 45, X mosaic karyotype.[19,20] Mosaic patients usually do not have the typical manifestations seen with patients with monosomy X, so are at a higher risk of misdiagnosis.[21] Nevertheless, early diagnosis and treatment are important for the prognosis of TS patients.[22] For example, patients can reach normal heights if given growth hormone from 2 to 5 years of age.