The changes of microcirculation can be used as an effective index to evaluate the severity of the disease, the efficacy of drugs and the monitoring of the disease.[2] Vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of psoriasis by promoting angiogenesis.[4,5] Because of its complex pathogenesis, psoriasis can not be cured completely at present. This evidence concerns the gene VEGFA and psoriasis.