GPT and neoplasm: The risk for HCC development is increased for patient with HBV infection.[5,6] Recent studies also showed that tumor recurrence after curative treatment of HCC was increased with the level of HBV-DNA and alanine aminotransferase (ALT).[2,7] Studies of large cohorts from China Hong Kong, China Taiwan, and Japan have confirmed that concomitant antiviral therapy with curative treatment reduced the recurrence of HCC.[8–22] However, there was no consensus about which kind of oral antiviral treatment was the best option in the prevention of HBV-related HCC recurrence after curative treatment.